Alterations in the salivary proteome associated with periodontitis

Haigh, Brendan and Stewart, Kevin and Whelan, John and Barnett, Matthew and Smolenski, Grant and Wheeler, Thomas (2010) Alterations in the salivary proteome associated with periodontitis. Journal of Clinical Periodontology, 37 (3). pp. 241-247. ISSN 1600-051X

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Abstract or Summary

Aim: To identify changes in the salivary proteome associated with active periodontitis. Materials and Methods: Quantitative proteomics (two dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis ) was used to investigate whole saliva from individuals with severe periodontitis, comparing their proteomic profile before and after periodontal treatment. Results: A comparison of 128 proteins across all saliva samples identified fifteen protein spots with altered abundance. The predominant alteration observed was an increase in the abundance of the S100 proteins S100A8/A9/A6. Of the remaining proteins with altered abundance, haptoglobin, prolactin inducible protein and parotid secretory protein have previously been associated with host defence. Conclusion: These results highlight the predominant involvement of S100 proteins in the host response during periodontitis, identify host defence components which have not previously been linked to this disease and suggest new potential biomarkers for monitoring disease activity in periodontitis.

Item Type:Journal article
Keywords that describe the item:periodontitis, proteomic, saliva
Subjects:R Medicine > RK Dentistry
Q Science > QP Physiology
Divisions:Schools > Centre for Science and Primary Industries
ID Code:271
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Deposited On:03 Dec 2010 03:03
Last Modified:03 Dec 2010 03:03

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