Pancreatic proglucagon products as unexpected modulators of insulin secretion

Stewart, Kevin and Phillips, Anthony R. J. and Whiting, Lynda and Cooper, Garth J. S. (2013) Pancreatic proglucagon products as unexpected modulators of insulin secretion. In: Medical Sciences Congress 2013, 26-28 August, 2013, Queenstown, New Zealand. (Unpublished)

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Conventional wisdom holds that while insulin from pancreatic β cells has a feedback inhibitory action on glucagon from α cells, the reverse does not occur, and that glucagon (and all other known α pancreatic cell hormones) stimulate insulin release. Here we use an isolated rat pancreatic perfusion model to demonstrate that α cell peptides can inhibit the release of insulin in response to hyperglycaemia. Infusion of glucagon (1 nM) markedly suppressed the insulin response to 20 mM glucose infusion. In an earlier study we identified a peptide similar to the alpha cell peptide glicentin-related pancreatic polypeptide (GRPP) that was present in greater quantities in islets from diabetic rats than normal rats. We have designated this peptide GRPP-like peptide (GRPP-LP)). GRPP and GRPP-LP originate from a different part of the proglucagon molecule than glucagon. Both also greatly attenuated the insulin response to hyperglycaemia. These observations may challenge some of the fundamental assumptions of the control of insulin release and help explain the associated with the genesis and progression of diabetes mellitus.

Item Type:Conference or Workshop Item (Speech)
Additional Information:page3A.6 Pancreatic proglucagon products as unexpected modulators of insulin secretion Kevin W. Stewart ARJ Phillips Whiting. GJS Cooper School of Engineering,Science & Primary Industries, Waikato Institute of Technology, Hamilton, Department of Surgery, University of Auckland School of Biological Sciences, University of Auckland, 4 Maurice Wilkins Cen tre for Molecular Biodi scovery, University of Auckland, 5 Centre for Advanced Discovery and Experimental Therapeutics, University of Mancheste
Keywords that describe the item:glucagon, hyperglycaemia, hypoinsulinaemia, mellitus
Subjects:Q Science > QP Physiology
Divisions:Schools > Centre for Science and Primary Industries
ID Code:2854
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Deposited On:20 Feb 2014 01:18
Last Modified:10 Aug 2015 04:39

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