The single cell gel or comet assay is a method used
to determine the genotoxicity of substances. It is
however both time and material intensive. In order
to overcome these limitations a high throughput
method using 96-well multi chamber plates was
examined as a method to analyse the effect of a
prebiotic (inulin) on detoxification of 2-amino-1-
methyl-6-phenylimidazo (4, 5-b) pyridine (PhIP)
[1], a carcinogenic heterocyclic amine formed
during cooking of meat, using an in vitro model of
colonic fermentation with human faecal microbiota