Targeted images of KB cells using folate-conjugated gold nanoparticles

Rathinaraj, Pierson and Kang, InnKyu (2015) Targeted images of KB cells using folate-conjugated gold nanoparticles. Targeted images of KB cells using folate-conjugated gold nanoparticles, 10 (1). pp. 1-14. ISSN December 2015Nanoscale Research Letters 10(1):5

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Abstract or Summary

Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.

Item Type:Journal article
Keywords that describe the item:Mercaptosuccinic acid-coated gold, Folic acid, Cancer
Subjects:Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions:Corporate > Research Office
ID Code:5682
Deposited By:
Deposited On:16 Jan 2018 20:48
Last Modified:19 Dec 2018 22:39

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