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[(ca)-5.5(l)-248.4(a)9(nd)-247.1(c)6.5(h)3.7(emica)-5.5(l)-248.4(p)11.8(r)12.4(o)10.4(p)-9(er)-10.2(t)-5.8(i)-0.3(es)-246.4([)]TJ 0 g 11.6219 0 TD ()Tj 0 0 0 1 k 0.3379 0 TD -0.0011 Tc [(],)-249.2(s)4.5(u)-1.3(c)5.4(h)-250.3(as)-249.3(t)8.5(u)-1.3(na)7(b)6.4(l)-1.1(e)-249.1()10.6(uo)10.2(r)11.3(e)-0.7(s)-9(c)-0.9(ence)]TJ -11.9598 -1.1906 TD -0.0005 Tc [(wa)17.5(v)7.2(e)3.5(len)7.2(g)-0.5(t)-7.2(h)-407.8(b)16.1(y)-408.7(size)6.2(,)-408.5(a)-408(sha)8.5(r)-10.7(p)-407.9(a)8.5(nd)-406.6(symmet)-6.3(r)-7.1(i)-0.8(ca)-6(l)-407()11.2(uo)10.8(r)11.9(e)-0.1(s)-8.4(c)-0.3(ence)]TJ 0 -1.1916 TD -0.0095 Tc [(p)-18.5(e)-15.4(a)-15(k)-9.5(,)-193.4(s)-3.9(t)-15.3(r)2.9(ong)-191.9(a)-0.5(n)-6.3(d)-193.4(s)-3.9(t)-16.2(abl)-9.4(e)-194.3(e)-9.1(m)-9.9(i)-7.1(s)-3.9(s)-9.3(i)-9.8(on)-10(,)-193.4(h)-9.4(i)-9.8(g)-16.7(h)-192.8(q)0.1(u)-12.4(a)-0.5(n)9(t)0.1(u)-9.7(m)-193.3(y)-12.1(i)-9.8(e)-5.5(l)-9.4(d,)-194.3(br)-16.1(i)-9.8(g)-16.7(h)9.6(t)-9.8(-)]TJ 0 -1.141 TD -0.0027 Tc [(ness,)-163.2(a)6.3(nd)-163.1(pho)7.7(t)3.3(o)-163.9(s)2.9(t)-9.4(a)5.4(b)9.3(i)-8.4(li)8.7(t)-5.8(y)-163.4([)]TJ 0 g 9.92 0 TD 0 Tc ()Tj 0 0 0 1 k 0.4616 0 TD ()Tj 0 g 0.5203 0 TD ()Tj 0 0 0 1 k 0.4535 0 TD 0.0054 Tc [(])5.3(.)-155.1(C)-9.9(o)16.7(m)24(p)0(a)14.4(r)17.8(ed)-155(wi)16.8(th)-155.3(th)9.1(e)-155(t)-0.4(r)5.1(a)5.4(d)5.8(i)16.8(ti)5.1(o)16.7(n)7.7(al)]TJ -11.3554 -1.141 TD -0.0014 Tc [(d)6.2(y)6.8(es)-315.5(a)7.6(n)1.8(d)-313.5()10.3(uo)9.9(r)11(e)-1(s)-9.3(c)-1.2(en)17.1(t)-314.3(p)10.4(r)11(o)9(t)4.6(e)-1(in)6.3(s)-312.8(u)1.1(s)-9.3(e)-6.4(d)-313.5(a)1.3(s)-314.6(i)-1.7(mag)-6.8(i)-1.7(n)6.3(g)-313(p)10.4(r)11(ob)-10.1(es,)-314.5(Q)7.3(D)4.6(s)]TJ T* -0.0071 Tc [(ha)10.9(ve)-541.5(s)-15(e)-14.8(ve)-6.7(r)-7.4(a)-12.6(l)-542.7(a)-7.1(dv)-7.5(an)11.4(t)-13.8(a)-1.7(ge)-6.7(s)-6.9(,)-542.5(su)-7.3(ch)-543.6(as)-541.7(tu)-7.3(n)-4.8(a)1(bl)-7(e)-542.4(e)-6.7(m)-7.5(i)-4.7(ss)-6.9(i)-7.4(o)4.2(n)-541.4(f)-17.3(rom)]TJ T* -0.0004 Tc [(visib)7.1(l)-0.3(e)-375.8(t)5.6(o)-376.6(i)-0.7(nf)-10.6(ra)8.6(r)12(e)-5.4(d)-374(w)-0.2(a)17.6(v)7.3(elen)7.3(gt)-7.1(h)7.8(s)-0.2(,)-376.8(b)11.6(r)12(o)-6.2(ader)-375.6(ex)8.2(ci)11(t)-7.1(a)18.5(t)-6.2(i)-0.7(o)10.9(n)-374.9(s)5.2(p)-9.4(e)-5.4(c)-7.4(t)-6.2(r)-0.7(a,)]TJ T* 0.3417 Tc [(a)350.7(n)344.9(dh)341.8(i)341.4(g)334.5(hr)354.1(e)342.1(s)341.9(i)344.1(s)347.3(t)335(a)350.7(n)344.9(c)341.9(et)347.7(op)349(h)345.4(o)352.1(t)347.7(o)346.7(b)349.2(l)341.8(e)335.8(a)341.7(c)348.2(h)341.8(i)341.4(n)349.4(g[)]TJ 0 g 16.286 0 TD 0 Tc ()Tj 0 0 0 1 k 0.495 0 TD (,)Tj 0 g 0.57 0 TD (\012)Tj 0 0 0 1 k 0.4634 0 TD 0.0001 Tc [(].)-342.8(H)25.3(o)15.9(w)8.5(e)-7.6(v)7.8(e)0.5(r)63(,)-342.8(t)-6.6(h)3.8(e)]TJ -17.8146 -1.141 TD -0.002 Tc [(p)-11(o)8.4(ten)16.5(t)-7.8(i)-5(a)-7.5(l)-279.3(a)16.9(p)8.9(p)5.3(lic)-4.5(a)16.9(t)-7.8(i)-2.3(o)9.3(n)5.7(s)-279.1(o)9.3(f)-279.6(Q)6.7(Ds)-280.9(in)-280.7(b)10(i)-2.3(olog)-26.3(y)-279.3(a)7(nd)-280.7(me)-7(dicine)-278.9(w)6.4(e)-1.6(r)10.4(e)]TJ T* -0.006 Tc [(l)-5.9(i)-6.3(m)-6.4(i)5.4(te)-11(d)-494.3(d)6.2(u)-6.2(e)-496.1(to)-496(t)-12.7(h)-2.3(e)-5.6(i)-6.3(r)-495(t)0(o)9.8(x)-5.6(i)-6.3(c)-495.4(e)-5.6()3(e)-11(c)-13(t)-6.3(s)-496.3([)]TJ 0 g 14.7882 0 TD 0 Tc ()Tj 0 0 0 1 k 0.4752 0 TD 0.0001 Tc [(].)-491(Q)8.8(D)6.1(s)-489.3(c)0.3(o)11.4(n)18.6(t)-6.6(a)9.1(in)-488.2(t)6.1(o)15.9(xic)]TJ -15.2634 -1.141 TD -0.0003 Tc [(co)11(m)18.3(p)-9.3(o)11(n)2.9(en)18.2(ts)-254.8(s)5.3(u)-0.5(c)6.2(h)-258.6(as)-257.5(cadmi)11.1(u)-0.5(m)-258.1(o)11(r)-256.2(l)-0.2(e)-6.2(a)-0.3(d)6.4(.)-259.2(C)-15.5(d)]TJ /F4 1 Tf 6.9738 0 0 6.9738 218.745 111.666 Tm -0.0005 Tc (2+)Tj /F1 1 Tf 9.9626 0 0 9.9626 229.464 107.2831 Tm -0.009 Tc [(an)-5.8(d)-266(P)-8.8(b)]TJ /F4 1 Tf 6.9738 0 0 6.9738 257.652 111.666 Tm -0.0005 Tc (2+)Tj /F1 1 Tf 9.9626 0 0 9.9626 268.371 107.2831 Tm -0.0002 Tc [(co)10.2(u)-5.8(l)-0.1(d)]TJ -21.8608 -1.141 TD 0.0068 Tc [(be)-346(r)19.2(e)10.8(l)6.9(e)0.9(a)9.5(s)-1.1(ed)-344.2(fr)19.2(o)18.1(m)-344.1(Q)15.5(D)12.8(s)-345.3(a)15.8(n)10(d)-344.2(th)10.5(e)7.2(n)-345.1(kill)-344.6(th)10.5(e)-345.1(c)7(e)10.8(l)1.4(l)9.6(s)-345.3([)]TJ 0 g 19.0856 0 TD 0 Tc ()Tj 0 0 0 1 k 0.4878 0 TD 0.0012 Tc [(].)-351.7(Recen)19.7(t)-5.5(l)8.5(y)74.4(,)]TJ -19.5734 -1.141 TD 0.0002 Tc [(a)-485(n)18.7(um)9.8(b)-8.5(e)0.6(r)-485.2(o)11.5(f)-484.3(t)6.2(ec)6.7(hniq)9.8(ues)-485.6(s)5.8(uc)6.7(h)-486.6(a)2.9(s)-484.7(a)-485(g)8.4(o)7(ld)-485.4(o)10.6(u)11.8(t)6.2(e)0.6(r)-485.2(s)4(hel)-5.2(l)-484([)]TJ 0 g 22.7009 0 TD -0.0056 Tc ()Tj 0 0 0 1 k 0.8257 0 TD 0.0001 Tc (],)Tj -23.5266 -1.141 TD -0.0004 Tc [(t)-7.1(a)8.6(r)7.4(g)7.8(et)5.6(e)-5.4(d)-180.7(liga)8.6(nd-li)-6.1(k)8.7(e)-180.7(p)-9.4(e)0(p)10.5(t)-6.2(ide)-180.7([)]TJ 0 g 11.4196 0 TD 0 Tc ()Tj 0 0 0 1 k 0.4517 0 TD [(],)-181.2(p)11.8(r)12.4(o)10.4(t)6(ein)7.7(s)-179.5([)]TJ 0 g 4.5476 0 TD -0.0001 Tc ()Tj 0 0 0 1 k 0.6757 0 TD 0 Tc (,)Tj 0 g 0.4083 0 TD 0.0026 Tc ()Tj 0 0 0 1 k 0.8067 0 TD -0.0002 Tc [(],)-180.5(a)8.8(n)3(d)-180.5(p)-9.2(o)6.6(l)7.1(ymer)]TJ -18.3096 -1.141 TD 0.0001 Tc [(co)-5.7(a)19(t)-5.7(in)7.8(g)-157.9([)]TJ 0 g 3.4482 0 TD -0.0001 Tc ()Tj 0 0 0 1 k 0.7877 0 TD 0.0029 Tc [(])-155.3(h)5.7(a)20.9(v)10.6(e)-154.8(b)-5.8(ee)3.3(n)-155.6(d)3.3(ev)10.6(e)6.9(l)3(o)13.3(p)-6.1(ed)-154.8(t)8.9(o)-155.6(minimize)-154.8(th)6.6(e)-154.8(c)-13.1(y)3(t)8.9(o)13.3(t)8.9(o)18.7(x)3.3(ic)3.1(i)14.3(t)-0.2(y)]TJ -4.2359 -1.141 TD -0.0097 Tc [(of)-411.1(QD)-3.7(s)-9.5(.)-413.2(C)-25(o)1.6(ns)-17.6(e)-14.7(q)-0.1(u)-9.9(e)-9.3(n)8.8(t)-16.4(ly)63.6(,)-409.5(m)-7.4(an)12.4(y)-410.7(a)9.2(ppro)-15.5(a)-9.7(c)-3.2(h)-6(e)-9.3(s)-410.6(f)-1(or)-411.1(t)-15.5(r)-10(ans)-9.5(f)-1(or)-16.3(m)-10.1(i)-10(ng)]TJ 25.8998 22.7849 TD -0.0102 Tc [(QD)-4.2(s)-288.2(f)-20.5(rom)-287(h)12.5(yd)-9.8(rop)-2.9(h)-6.5(o)-5.2(b)1.8(i)-10.5(c)-286.4(t)-4.2(o)-288.9(h)12.5(y)-2(d)-9.8(r)2.2(op)-2.9(h)-10.1(i)-15.9(l)-10.2(i)-10.5(c)-286.4(h)-7.4(a)7.8(v)-2.5(e)-288(b)-18.9(e)-15.2(e)-9.8(n)-288.9(d)-9.8(e)-17.9(v)-2.5(e)-6.2(l)-10.2(op)-19.2(e)-15.2(d)]TJ 0 -1.1419 TD 0.0003 Tc [(f)9(o)11.6(r)-457.1(v)-0.1(a)9.3(r)-6.3(io)10.7(us)-455.7(b)12.3(i)0(o)11.6(m)3.5(edica)-5.2(l)-456.8(a)19.2(p)11.2(p)7.6(l)0.3(ica)19.2(t)-5.5(io)11.6(n)8(s)0.5(.)-457.4( )3.5(er)12.7(ef)9(o)11.6(r)12.7(e)7(,)-457.4(a)-5.2(l)12.1(t)6.3(e)0.7(r)-6.3(n)2.6(a)19.2(t)-5.5(i)7.2(v)8(e)]TJ 0 -1.141 TD -0.0009 Tc [(r)11.5(e)-0.5(s)-8.8(e)-6.8(a)8.1(r)11.5(c)5.6(h)2.8(er)5.1(s)-400.9(h)1.9(a)17.1(v)6.8(e)-399.8(a)-6.4(ls)-8.8(o)-398.8(u)1.6(s)-8.8(e)-5.9(d)-399.8(n)2.3(o)10.4(n)2.3(c)-16.9(y)-0.8(t)5.1(o)9.5(t)5.1(o)14.9(xic)-397.3(m)1.4(a)18(t)5.1(er)-7.5(ia)-6.4(ls)-399.1(s)4.7(u)-1.1(c)5.6(h)-401(as)]TJ T* -0.0008 Tc [(p)-9.8(o)6(l)6.5(y)7.4(et)-7.5(h)21.9(y)-7.9(lene)-303(g)-8(l)6.5(y)7.4(c)-0.6(o)6(l)-304.3(\(P)4.8(EG\))-304.3(a)8.2(nd)-303(p)-9.8(o)6(l)6.5(y)-3.4(ma)-6.3(leic)-303.2(a)8.2(n)-6.7(h)21.9(y)7.4(dr)-7.4(ide)-302.1(s)-6.9(a)-6.3(l)11(t-)49(-)]TJ T* 0.0058 Tc [(t)11.8(e)6.2(tr)5.5(a)5.8(d)6.2(ec)6(e)6.2(n)9(e)-288.3(t)11.8(o)-288.2(c)6(oa)24.7(t)-287.2(t)-0.9(h)9.5(e)-287.4(s)11.4(u)5.6(rf)5.5(a)5.8(c)6(e)6.2(s)-287.6(o)17.1(f)-288.1(Q)14.5(D)11.8(s)-287.6([)]TJ 0 g 16.6049 0 TD -0.0164 Tc ()Tj 0 0 0 1 k 0.8194 0 TD -0.0005 Tc [(].)-294.7(D)-7.2(e)-0.1(p)-9.5(e)-0.1(ndin)7.2(g)-293.1(o)10.8(n)]TJ -17.4243 -1.141 TD 0.0013 Tc [(t)-5.4(h)5(e)-282.9(a)20.2(p)12.2(p)8.6(lica)20.2(t)-4.5(i)1(o)12.6(n)9(s,)-282.9(s)6.9(u)1.1(r)-5.3(f)1(ace)-283.8(m)4.5(o)-8.1(d)1.7(i\015ca)20.2(t)-4.5(i)1(o)12.6(n)9(s)-281.2(o)12.6(f)-282.7(Q)10(D)7.3(s)-283.9(a)10.3(r)13.7(e)-282.9(r)13.7(eq)10.9(uir)13.6(e)-3.7(d)8(.)]TJ T* 0.0005 Tc [(F)19.1(o)11.8(r)-430.7(exa)9.5(m)19.1(p)7.8(le)7.2(,)-432.8(b)12.5(io)11.8(me)-4.5(dica)-5(l)-429.5(a)19.4(p)11.4(p)7.8(lica)19.4(t)-5.3(i)0.2(o)11.8(n)8.2(s)-430.2(r)12.9(e)-4.5(q)10.1(uir)12.9(e)-429.1(hig)-6.7(h-q)10.1(ua)-5(li)11.9(ty)]TJ T* -0.0061 Tc [(w)-5.9(a)12.8(te)-5.7(r)-234(s)-14(ol)5.7(ubl)-6(e)-232.4(and)-232.4(n)-2.9(o)5.2(n)12.4(to)9.7(x)-5.7(i)-6.4(c)-230.8(Q)2.6(Ds)-5.9(.)]TJ 1.5005 -1.141 TD -0.0007 Tc [(S)-14.5(o)-190.8(fa)8.3(r)62.2(,)-190.1(n)17.8(u)-0.9(mer)11.7(o)9.7(us)-188.4(mo)-10.1(di\015ca)18.2(t)-6.5(io)10.6(n)7(s)-188.4(o)10.6(f)-189.8(Q)8(D)5.3(s)-190.2(s)4.9(ur)-7.3(face)-190.9(c)5.8(h)3(emis)4.9(t)-6.5(r)-29.9(y)]TJ -1.5005 -1.141 TD -0.0012 Tc [(ha)16.8(v)6.5(e)-425.4(b)-9.9(e)-6.2(en)-426.2(exp)6.1(lo)10.1(r)11.2(e)-6.2(d)5.5(,)-426.3(inc)5.3(l)10.6(udin)6.5(g)-423.9(t)-7.9(he)-424.5(a)17.7(t)8.4(t)-7.9(a)-1.2(c)5.3(h)-1.1(men)17.3(t)-424.3(o)10.1(f)-425.2(mer)11.2(c)-3.7(a)17.7(p)-1.2(-)]TJ T* 0 Tc 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