The host microbiome and impact of tuberculosis chemotherapy

O’Toole, Ronan F. and Gautam, Sanjay S. (2018) The host microbiome and impact of tuberculosis chemotherapy. Tuberculosis, 113 . pp. 26-29. ISSN 14729792

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Abstract or Summary

The treatment of Mycobacterium tuberculosis infection is often viewed in isolation from other human microbial symbionts. Understandably, the clinical priority is eliminating active or latent tuberculosis (TB) in patients. With the increasing resolution of molecular biology technologies, it is becoming apparent that antibiotic treatment can perturb the homeostasis of the host microbiome. For example, dysbiosis of the gut microbiota has been associated with an increased risk of the development of asthma, obesity and diabetes. Therefore, fundamental questions include: Does TB chemotherapy cause disruption of the human microbiome and adverse effects in patients; and are there signature taxa of dysbiosis following TB treatment. In this review, we examine recent research on the detection of changes in the microbiome during antibiotic administration and discuss specific findings that relate to the impact of anti-tubercular chemotherapy.

Item Type:Journal article
Keywords that describe the item:tuberculosis, chemotherapy
Subjects:Q Science > QR Microbiology
R Medicine > RA Public aspects of medicine
Divisions:Schools > Centre for Health & Social Practice
ID Code:7194
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Deposited On:11 Feb 2020 01:15
Last Modified:06 May 2020 21:10

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