Metabolomics of post-mortem blood: identifying potential markers of postmortem interval

Donaldson, Andrea (2014) Metabolomics of post-mortem blood: identifying potential markers of postmortem interval. Metabolomics, 11 (1). ISSN 1573-3882

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Official URL: https://link.springer.com/article/10.1007/s11306-0...

Abstract or Summary

Death results in changes in some metabolites in body tissues due to lack of circulating oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic production of metabolites and macromolecules. Metabolic changes may provide chemical markers to better determine the time since death (post-mortem interval), something that is challenging to establish with current observation-based methodologies. The aim of this research was to carry out a metabolic analysis of blood plasma postmortem,inordertogainamorecompleteunderstandingofthe biochemical changes that occur following death. Gas chromatography was used to conduct a survey of post-mortem rat blood. Sixty six metabolites were detected post-mortem. Twenty six of these [18 amino acids, glutathione (GSH), 4-Amino-n-butyric acid (GABA), glyoxylate, oxalate, hydroxyproline, creatinine, a-ketoglutarate and succinate] had increased concentrations post-mortem. The remaining 40 metabolites had concentrations that were not dependant on time. This study demonstrates the range of metabolic changes that occur post-mortem as well as identifying potential markers for estimating post-mortem interval.

Item Type:Journal article
Keywords that describe the item:Post-mortem interval, Biochemical markers, Blood metabolites, Hypoxia, GC–MS, Forensic science, Amino acids
Subjects:K Law > K Law (General)
Q Science > QD Chemistry
R Medicine > RB Pathology
Divisions:Schools > Centre for Health & Social Practice
ID Code:7336
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Deposited On:08 May 2020 03:42
Last Modified:08 May 2020 03:42

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