Tag Team Patient Safety Simulation (TTPSS) was developed to overcome the challenges associated with providing meaningful and engaging patient safety simulations to large groups of learners. In TTPSS each participant and observer has a specific, active and integral role in the simulation and purpose-built facilities and expensive equipment are not required. This approach enables flexibility in terms of location and group size, while at the same time creating an immersive experience for all learners. Although TTPSS has been designed for undergraduate nursing students, the approach can be easily transferred to other health disciplines.