Effects of regular aerobic exercise on neural function in persons with Alzheimers Disease

Milham, Don J. (2010) Effects of regular aerobic exercise on neural function in persons with Alzheimers Disease. In: Alzheimers New Zealand Conference 2010, 6-8 May, 2010, Wellington, New Zealand.

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Abstract or Summary

Objective: This study examined the AD/exercise hypothesis which posits exercise enhances neural function and attenuates AD symptoms/delays onset through enhanced expression of Brain-derived neurotrophic factor; a peptide that plays a major role in neural function and the mediation/attenuation of the primary AD pathogen, ß-amyloid. Methods: Participants (N = 19; mean 85.5 yrs, SD = + 5.20) diagnosed with probable AD completed a single treatment, regular walking over time (30-min, 3 days per week for 12 weeks); pre/post-test evaluations measured cognitive function and motor capabilities. Statistics - T-test with repeated measures ANOVA with various categorical variables as between-group factors. Results: Along with significant reduction in falls (z = 2.392, p < .017), change in Cognitive function [t(18) = 5.74, p < .001], Balance [t(18) = 7.43, p < .001], and Mobility [t(18) = 3.82, p < .001] were significant. No main effect was associated with AD stage, Activities of daily living, Gender, or Education level. Conclusion: Along with illustrating the positive effects exercise can have in the elderly, results of this study support the exercise hypothesis positing regular aerobic exercise enhances neural function in persons with probable AD, thus possibly attenuating AD symptoms and delaying AD onset.

Item Type:Conference or Workshop Item (Lecture)
Keywords that describe the item:Exercise hypothesis, neural function, cognition, balance, mobility
Subjects:Q Science > QP Physiology
Divisions:Schools > School of Science and Primary Industries
ID Code:859
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Deposited On:02 Mar 2011 01:39
Last Modified:02 Mar 2011 01:39

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