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Targeted images of KB cells using folate-conjugated gold nanoparticles


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Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.

Item Type: Journal article
Uncontrolled Keywords: Mercaptosuccinic acid-coated gold, Folic acid, Cancer
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Corporate > Research Office
Depositing User: Pierson Rathinaraj
Date Deposited: 16 Jan 2018 20:48
Last Modified: 21 Jul 2023 04:50

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