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The host microbiome and impact of tuberculosis chemotherapy


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The treatment of Mycobacterium tuberculosis infection is often viewed in isolation from other human microbial
symbionts. Understandably, the clinical priority is eliminating active or latent tuberculosis (TB) in patients. With the increasing resolution of molecular biology technologies, it is becoming apparent that antibiotic treatment can perturb the homeostasis of the host microbiome. For example, dysbiosis of the gut microbiota has been associated with an increased risk of the development of asthma, obesity and diabetes. Therefore, fundamental questions include: Does TB chemotherapy cause disruption of the human microbiome and adverse effects in patients; and are there signature taxa of dysbiosis following TB treatment. In this review, we examine recent research on the detection of changes in the microbiome during antibiotic administration and discuss specific findings that relate to the impact of anti-tubercular chemotherapy.

Item Type: Journal article
Uncontrolled Keywords: tuberculosis, chemotherapy
Subjects: Q Science > QR Microbiology
R Medicine > RA Public aspects of medicine
Divisions: Schools > Centre for Health & Social Practice
Depositing User: Ronan Otoole
Date Deposited: 11 Feb 2020 01:15
Last Modified: 21 Jul 2023 08:41

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